M1 Macrophage-Derived Exosomes Loaded with RSL3 Enhance Ferroptosis and Modulate the Tumor Microenvironment for Improved Cancer Immunotherapy

Editor: Tiffany A novel therapeutic strategy using M1 macrophage-derived exosomes loaded with the ferroptosis inducer RSL3 has been shown to effectively accumulate in tumors, induce ferroptosis, and reprogram the immunosuppressive…

Cloud α AX12: A Cutting-Edge Lung-on-Chip Inhalation Platform for Nanoparticle Toxicity and Drug Efficacy Testing

Editor: Nina Scientists develop the Cloud α AX12 inhalation platform, an innovative lung-on-chip system combined with cloud-based aerosol exposure technology, to accurately assess inhalation toxicity and drug efficacy in respiratory…

Prebiotic Nanoparticle Enhances Capecitabine Delivery and Modulates Gut Microbiota for Improved Colorectal Cancer Therapy

Editor: Tiffany Researchers have developed a prebiotic nanoparticle that significantly improves the delivery of capecitabine to colorectal cancer tumors while modulating gut microbiota to enhance anti-tumor immunity, offering a promising…

Fluorinated Polyamidoamine Dendrimers Enhance miR-23b Delivery for Effective Treatment of Rheumatoid Arthritis

Editor: Nina Scientists develop fluorinated polyamidoamine dendrimer-mediated nanoparticles for targeted delivery of microRNA-23b, effectively reducing inflammation and promoting apoptosis in rheumatoid arthritis models. Key Preview Research QuestionThe study investigates whether…

New Inhalation Platform Enhances Preclinical Research for Respiratory Diseases

Editor: Tiffany Researchers have unveiled an innovative multiplex inhalation platform, the Cloud α AX12, designed to accurately model aerosol delivery in a dynamic lung-on-chip environment, enhancing the study of inhalation…

Combination Chemotherapy Targets Ovarian Cancer with Reduced Toxicity

Editor: Sarah A recent study explores a new approach for the treatment of high-grade serous ovarian cancer (HGSOC), a particularly aggressive form of ovarian cancer. This study investigates the combination…

Targeted Chemo-Photothermal Cancer Therapy Using Doxorubicin-Loaded Liposomal Iron Oxide Nanoparticles

Editor: Nina Scientists develop doxorubicin-loaded liposomal iron oxide nanoparticles for targeted chemo-photothermal cancer therapy, enhancing tumor accumulation and therapeutic efficacy through magnetic and laser-induced heating. Key Preview Research Question This…

Novel Microneedle Patch Shows Promise in Treating Hair Loss

Editor: Tiffany A new microneedle patch delivering a curcumin-zinc framework has shown promising results in promoting hair growth by simultaneously addressing oxidative stress, zinc deficiency, and hormonal factors in hair…