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Targeting Mitochondrial DNA with Rh-Mito to Enhance Cancer Immunotherapy
Editor: Tiffany Researchers have developed Rh-Mito, a small molecule that targets mitochondrial DNA to activate the cGAS-STING pathway, enhancing cancer immunotherapy by triggering immune responses and altering epigenetic regulation. Key…
Innovative Carbon Dots-Based Therapy Offers New Hope Against Drug-Resistant Lung Cancer
Editor: Tiffany Researchers have developed a carbon dots-based nanozyme that co-delivers doxorubicin and siRNA to effectively address drug-resistant lung cancer, potentially enhancing treatment options for affected patients. Key Highlights Context…
Innovative Approach to Colorectal Cancer Treatment: Combining Gut Microbiota Modulation with Chemotherapy
Editor: Nina Researchers create a capecitabine-loaded prebiotic nanoparticle that enhances colorectal cancer treatment through gut microbiota modulation and improved drug delivery, leading to increased therapeutic efficacy and reduced side effects.…
A New Approach to Enhancing Immune Response in Pancreatic Cancer Treatment
Editor: Tiffany Researchers have developed a novel hydrogel microsphere vaccine that significantly boosts immune responses against pancreatic cancer following ablation therapy, potentially improving patient survival rates. Key Highlights Pancreatic Cancer…
Fatostatin Induces Ferroptosis in Glioblastoma: A Promising New Approach
Editor: Nina Scientists reveal that fatostatin induces ferroptosis in glioblastoma cells by inhibiting the AKT/mTORC1/GPX4 signaling pathway and develop a p28-functionalized PLGA nanoparticle delivery system to enhance targeted treatment efficacy.…
pH-Responsive Magnetic Nanoparticles Improve Breast Cancer Therapy via Tumor Cell Aggregation and Immune Response
Editor: Tiffany A team from Sichuan University has developed pH-responsive magnetic nanoparticles that clump inside breast cancer cells, boosting the effectiveness of heat therapy and activating the immune system. Key…
Preclinical Proof of Concept for VivoVec: An Approach to CAR T-Cell Engineering
Editor: Nina Researchers introduce UB-VV100, an innovative lentiviral vector platform for in vivo CAR T-cell engineering that effectively targets B-cell malignancies while eliminating the need for ex vivo manufacturing and…
Advancements in Nerve Repair: A Multifunctional Conduit for Peripheral Nerve Regeneration
Editor: Nina Researchers develop a multifunctional nerve guidance conduit integrating a density gradient of aFGF-encapsulated collagen nanoparticles and electrospun fibers to enhance peripheral nerve regeneration and functional recovery. Key Preview…