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AAV-Driven ANGPTL3 Gene Editing Achieves Significant Lipid Reduction in Mice
Scientists have successfully utilized a hepatocyte-specific base editing strategy via dual-AAV delivery to achieve a remarkable reduction in blood lipid levels in mice by targeting ANGPTL3. Background — Targeting ANGPTL3:…
Novel Biodegradable Hemostatic Nanocomposite Revolutionizes Bleeding Control and Liver Wound Healing
Researchers have developed a biodegradable nanocomposite incorporating decellularized liver extracellular matrix (L-ECM) and thrombin, demonstrating exceptional hemostatic efficiency and liver wound healing in preclinical models. The Challenge of Hemorrhage Control…
Innovative Nanoformulation Combines Ferroptosis and Immunotherapy to Revolutionize Cancer Treatment
Ferroptosis and Immunotherapy in Cancer Treatment Cancer immunotherapy has transformed oncological care by leveraging the immune system’s ability to target tumors. Despite its potential, challenges such as immune evasion and…
Innovative Breakthrough in Diabetic Wound Therapy: The Rise of Microneedle Technology
Introduction: A Persistent Challenge in Diabetic Wound TreatmentDiabetic wounds, affecting nearly 25% of patients with diabetes, have long posed a challenge to modern medicine due to their susceptibility to infection,…
Breaking Barriers in Cancer Treatment: The Promise of Nanoparticle-Mediated Radiosensitization
Pioneering Advances in Chondrosarcoma TreatmentChondrosarcoma, a malignant tumor arising from cartilage, has long presented a formidable challenge in oncology due to its resistance to conventional chemotherapy and radiotherapy. Factors such…
Breakthrough mRNA Therapy via Engineered Extracellular Vesicles Shows Promise for Alzheimer’s Treatment
A study published in the journal BMC Medicine demonstrates the potential of extracellular vesicle (EV)-based mRNA delivery to target and repair synaptic dysfunction in Alzheimer’s disease. Synaptic Dysfunction in Alzheimer’s…
AI-Driven Biosynthesis of Gold Nanoparticles: A Game-Changer in Antitumor Therapy
Recent advancements in artificial intelligence have enabled the optimization of gold nanoparticle (AuNP) biosynthesis, demonstrating significant anticancer potential both in vitro and in vivo. The Promise of Gold Nanoparticles Gold…
Unveiling the Hidden Mechanisms of Chemoresistance in Breast Cancer: A Study on Tumor-Associated Macrophages and HSP70
Introduction: The Evolution of Chemotherapy and the Rise of Resistance in Breast Cancer Chemotherapy has long been a cornerstone in the treatment of aggressive breast cancers, including triple-negative breast cancer…