Novel Nanospanlastics Enhance Oral Delivery of Resveratrol in Mice with Endotoxicity
Author: Tiffany Researchers have developed a new formulation using nanospanlastics that improves the oral bioavailability and therapeutic efficacy of resveratrol in a mouse model of lipopolysaccharide-induced endotoxicity, indicating a significant…
New Nanocarrier System Enhances Antimicrobial Activity of Ciprofloxacin Against Resistant Bacteria
Author: Tiffany Researchers have developed a novel nanocarrier system, ZnO@ZIF-8, that enhances the delivery and effectiveness of the antibiotic ciprofloxacin against antibiotic-resistant bacterial strains, potentially transforming treatment strategies for resistant…
Innovative Nanoemulsion Combats Hyperammonemia in Rats: Curcumin and Resveratrol Join Forces
Editor: Nina This study demonstrates that a curcumin-resveratrol nanoemulsion effectively mitigates hyperammonemia and its associated hepatic and cerebral dysfunctions induced by a protein-deficient diet in juvenile rats, highlighting its potential…
Novel P-Selectin-Targeted Nanocarriers Enhance Drug Delivery for Medulloblastoma Treatment by Crossing the Blood-Brain Barrier
A recent study shows that P-selectin-targeted nanocarriers can effectively cross the blood-brain barrier to deliver the cancer drug vismodegib directly to medulloblastoma tumors, potentially reducing harmful side effects. Key Highlights:…
Exosome-Based Therapy Shows Promise in Alleviating Alcohol-Associated Liver Injury in Mice
Editor: Nina This study demonstrates that exosome-based delivery of super-repressor IκBα (Exo-srIκB) effectively mitigates alcohol-associated liver injury in mice by targeting inflammation in Kupffer cells, highlighting its potential as a…
Development of Tumor-Specific Gene Nanomedicine to Improve T-Cell Recruitment and Activation in Melanoma Treatment
Author: Tiffany A recent study has developed a tumor-specific gene nanomedicine that enhances T-cell recruitment and activation, leading to improved effectiveness in the treatment of melanoma through immunotherapy. Key Highlights:…
New Vaccine Design Promises Broad Protection Against SARS-CoV-2 and Related Viruses
This study presents a computationally designed antigen, T2_17, which elicits broad humoral immune responses against SARS-CoV-2 and related sarbecoviruses, demonstrating potential for effective vaccine development to combat zoonotic spillovers and…
New Approach to Combat Paclitaxel-Resistant Lung Cancer: A Dual Nanoparticle Strategy
Editor: Nina This study presents a novel combination therapy using cabazitaxel-loaded human serum albumin nanoparticles and TGFβ-1 siRNA lipid nanoparticles, demonstrating enhanced efficacy and reduced toxicity in treating paclitaxel-resistant non-small…