Systemic Leptin-Mediated Delivery of Fas-Blocking Peptide Reduces Apoptosis in Ischemic Stroke
Editor: Tiffany A leptin-conjugated Fas-blocking peptide, delivered systemically, inhibits apoptosis and reduces brain damage in animal models of ischemic stroke by targeting Fas-expressing regions, offering a potential new treatment strategy.…
Shortwave-Infrared Probes: A New Frontier in Cancer Vaccine Tracking
Editor: Nina Scientists develop a shortwave-infrared light-emitting nanoparticle-based nanovaccine to enable real-time tracking of immune responses and effective eradication of cancer tumors in vivo. Key Preview Research Question This study…
New Hope for Glioblastoma: Combining Temozolomide and Doxorubicin
Editor: Tiffany Researchers have discovered that combining temozolomide and doxorubicin significantly enhances the effectiveness of glioblastoma treatment, particularly in drug-resistant cells, offering new hope for patients battling this challenging cancer.…
Strontium-Doped Bioactive Glass Coating Enhances Antibacterial Properties of Orthopedic Implants
Editor: Nina Scientists develop a strontium-doped bioactive glass and polydopamine functionalized polyetheretherketone implant system to enhance antibacterial efficacy and promote tissue repair against methicillin-resistant Staphylococcus aureus infections through photothermal therapy…
Tetrahedral Framework Nucleic Acids/Hyaluronic Acid-Methacrylic Anhydride Hybrid Hydrogel for Infected Wound Healing
Editor: Tiffany Introduction Infected wounds, particularly in the oral and maxillofacial regions, pose a significant challenge in clinical settings. These wounds often arise from trauma that exposes skin and oral…
Microbial Nanofactories: Boosting Cancer Immunotherapy with Biogenic Prussian Blue
Editor: Nina Scientists develop a mitochondria-targeting nanoplatform, MiBaMc, synthesized from Prussian blue nanoparticles using Shewanella oneidensis MR-1, to enhance checkpoint blockade immunotherapy and achieve significant tumor growth inhibition in triple-negative…
Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery to the Tumor Microenvironment Inhibits Colon Cancer Progression
Editor: Tiffany Researchers have developed an ionizable lipid nanoparticle (LNP) platform to deliver TRAIL mRNA directly to the tumor microenvironment, effectively inducing tumor cell death and inhibiting colon cancer progression,…
Cancer Treatment: A Novel Polymeric Nanodrug Enhances Chemoimmunotherapy
Editor: Nina Scientists develop a self-augmented ROS-responsive polymeric nanocarrier for synergistic chemoimmunotherapy that co-delivers paclitaxel and 1-methyl-D,L-tryptophan to enhance anti-tumor efficacy and modulate the immunosuppressive tumor microenvironmen. Key Preview Introduction…